Research Article – Mechanisms of Edible Bird’s Nest Extract-Induced Proliferation of Human Adipose-Derived Stem Cells
Edible bird’s nest (EBN) is the nest of the swift and is con- structed with salivary glue, which is a cementing substance, and may incorporate other materials such as vegetation or feathers. Although Edible bird’s nest mainly contains carbohydrates, amino acids, and mineral salts, its major ingredients are glycoproteins . Due to its nutritious and medical properties, Edible bird’s nest has been deemed a precious food tonic in Chinese community ever since the Tang (907AD) and Sung (960–1279 AD) dynasties .
Despite the long history of using Edible bird’s nest for medicinal purpose, there have only been a limited number of scientific reports on the health benefits of Edible bird’s nest. Recently, Edible bird’s nest has been found to potentiate mitogenic response of human peripheral blood monocytes  and stimulate DNA synthesis in 3T3 fibroblasts .
Growth factors such as epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) and cytokines such as interleukin-6 (IL-6) play an important role in cellular communication. As intercellular mediators, these molecules regulate survival, growth, differentiation, and effector functions of cells [5–8]. In the case of stem cells, the IL-6 family of cytokines has been known to be involved in the maintenance of both embryonic and adult stem cells [9, 10]. In addition, IL-6 was reported to increase the proliferation of placenta-derived multipotent mesenchymal stem cells (MSCs) . Rehman et al. also demonstrated that human adipose stromal cells secreted angiogenic and antiapoptotic growth factors, such as VEGF, and hepatocyte growth factor (HGF), in response to hypoxia and that conditioned media containing these growth factors increased cell growth and suppressed cell apoptosis .
Kyung-Baeg Roh,1 Jienny Lee,1 Young-Soo Kim,1 Junho Park,2 Jang-Hyun Kim,3 Jongsung Lee,1 and Deokhoon Park1
1 Biospectrum Life Science Institute, 442-13 Sangdaewon-Dong, Seongnam City, Gyeonggi Do 462-807, Republic of Korea
2 Skincure Life Science Institute, 66 Jejudaehakno, Jeju City, Jeju Special Self-Governing Province 690-756, Republic of Korea 3 Dermiskin Life Science Institute, 44-9 Cheongho Ri, Pyeongtaek City, Gyunggi Do 451-862, Republic of Korea